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KMID : 1038220230500010106
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Archives of Plastic Surgery
2023 Volume.50 No. 1 p.106 ~ p.115
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Is “Initial Size of the Graft the Real Culprit behind Primary Contraction of Full-Thickness Skin Graft”? ? A Cross-Sectional Study
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Madhubari Vathulya
Shalinee Rao
Akanksha Malik
Smita Sinha
Nikhilesh Kumar
Akshay Kapoor
Yogesh Bahurupi
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Abstract
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Background : Primary contraction of full-thickness graft has been traditionally quoted to be 40%. There are lacunae in literature to elaborate on the factors influencing it ever since.
Methods : About 75 subjects who underwent full-thickness grafting procedures to resurface small defects were included in the study. The initial and final graft dimensions after primary contraction were traced on X-ray templates and the percentage of contraction was evaluated using the graphical method. This was further correlated with age, collagen, elastic matrix metalloproteinases-1 (MMP-1) and -2 content along with dermal thickness of the skin specimen sent from the graft.
Results : The primary contraction of the graft had a very significant correlation only with the initial size of graft harvested with a linear regression of 33.3% and a Spearman's correlation of 0.587 significant at a p-value of 0.001.
Conclusion : This study though preliminary tries to highlight an important factor that primary contraction of grafts is a physical phenomenon independent of its contents like collagen, elastin, or MMP-1 and -2 or age and dependent on its initial size of harvest instead.
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KEYWORD
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skin grafts, elastin fibers, collagen, dermal thickness
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